Benzalkonium chloride (BAC) is one of the most common ingredients of the disinfectants. Although cell membrane damage has been considered as the main cytotoxic mechanism of BAC, its concentration- and time-dependent cellular effects on lung epithelium have not been fully understood. to Timolol Maleate IP + Benzalkonium chloride solution IP (as preservative) + Water for injection IP q.s. All products mentioned contain benzalkonium chloride. The highest quality reference standards for reliable results. BENZETHONIUM CHLORIDE is incompatible with strong oxidizing agents. IARC Category Benzalkonium chloride No No No None Section XII - Ecological Information This product is not expected to bioaccumulate. It can be difficult to determine the cancer risk of an ingredient, with the FDA and EU frequently coming to different conclusions. Benzalkonium Chloride: 0.004%: Vehicle Amount; Hypromellose 2910: 0.5%: Other Ingredients: Sodium Chloride, Polysorbate 20, Purified Water * May contain Hydrochloric Acid and/or Sodium Hydroxide to adjust pH. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1]. Ltd. provides the information contained herein in good faith but makes no Benzalkonium chloride sering digunakan sebagai campuran dalam berbagai produk obat, seperti obat tetes mata, obat tetes telinga, atau semprot hidung. Tell your doctor if you are pregnant or plan on getting pregnant. Basis for Listing: AB-IARC. Not natural, not safe: Grapefruit Seed Extract | Science ... Benzalkonium chloride 344 mg/kg (rat) >2000 mg/kg (rabbit) 0.054 - 0.51 mg/l mist The product is non-toxic by ingestion or inhalation. Regular use of products containing antimicrobials such as benzalkonium chloride could leads to the development of resistant bacteria in homes and food processing facilities. Breast Cancer Awareness Patriotic Campaign Trail Pets & Animals Charity Walks/Events Police Colleges and Universities Politics ... Benzalkonium Chloride Inact. Benzalkonium Chloride - an overview | ScienceDirect Topics Potassium Chloride (K-Lyte) 419 KB: 264: Baricitinib 500 KB: 265: Brimonidine IP + Brinzolamide IP + Timolol eq. Home Page: American Journal of Obstetrics & Gynecology It works by killing microorganisms and inhibiting their future growth, and for this reason frequently appears as an ingredient in antibacterial hand wipes, antiseptic creams and anti-itch ointments. This chemical can actually cause stains to develop on the teeth. Benzalkonium Chloride Towelettes - Medline Industries BAK is well documented to be toxic to the epithelial cells of the eyes. Benzalkonium Chloride - Uses, Side Effects, Information Label: HAND SANITIZER- benzalkonium chloride 0.1%w/w liquid. Is Benzalkonium Chloride Useful For Coronavirus (COVID-19 ... Benzalkonium chloride formulations for consumer use are dilute solutions. Concentrated solutions are toxic to humans, causing corrosion/irritation to the skin and mucosa, and death if taken internally in sufficient volumes. Human Lens Epithelial Cell Damage and Stimulation of Their Secretion of Chemical Mediators by Benzalkonium Chloride Rather Than Latanoprost and Timolol. Find patient medical information for ciprofloxacin ophthalmic (eye) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. benzalkonium chloride in mouthhwash Archives - Natural ... 8001-54-5 Benzalkonium Chloride < 1 % 144-55-8 Carbonic acid monosodium salt < 1 % 7732-18-5 Water > 99 % Section 4. Benzethonium chloride damages phospholipid membranes and may possibly affect α 7 and α 4 β 2 neuronal nicotinic acetylcholine receptors (48, 49). Check out our job openings! Furthermore, over the course of the 18 years covered by the various analyses, the actual antimicrobial compounds found in the putative grapefruit seed extracts changed from triclosan and methyl p-hydroxybenzoate in early samples to benzethonium chloride in the middle years to mixtures of benzalkonium and/or alkonium chlorides in more recent years. Applies to benzalkonium chloride topical: external liquid, external solution. Benzethonium chloride Avoid wearing lenses with signs and symptoms of … The C12-18 (carbon chain which is 12-18 carbon atoms in length) part of the name indicates the presence of alkyl groups 'Lauric (C12)', 'Tridecyclic (C13)', 'Myristic (C14)', 'Pentadecanoic (C15)', 'Palmitic (C16)', 'Margaric (C17)' and/or 'Stearic (C18)'. The zinc ionophore clioquinol was shown in mice to restore zinc levels and stop the growth of prostate tumors. Benzalkonium Chloride. Benzethonium chloride was nominated by the National Cancer Institute to the NTP for study from a class study of chemicals used as biocides. European Medicines Agency - For help on how to get the results you want, see our search tips. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1]. Home Page: Journal of Endodontics Documents Last updated on … Benzethonium Chloride, when crystallized from benzene, chloroform, or ether, forms thin hexagonal plates. Show More. Benzalkonium chloride is a well-known irritant [1]. 8001-54-5 - Benzalkonium chloride [INN:BAN:JAN:NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Bleach is a basic solution. Hives. o onta t len , if pre ent and easy to do. Tell your doctor if you are breast-feeding. Zat ini bekerja dengan cara menghentikan pertumbuhan beberapa jenis bakteri, virus, dan jamur. DEA Schedule: None. You will need to talk about the benefits and risks of using benzalkonium chloride while you are pregnant. Keep container tightly sealed,avoid contact with eyes ,wash hands after handing,not for use on broken or sensitive skin,stop use if skin irritation develops,flush eyes immediately if product enters eyes.Keep away from heat and flame.Call a poison control center or doctor for treatment advice.Have the product container label with you when calling a poison … Stable for two weeks at temperatures up to 140 F, (NTP, 1992). AJOG's Editors have active research programs and, on occasion, publish work in the Journal. BAC is a positively charged surface-active alkylamine and is a powerful cationic … ; Anal itching also can be caused by the irritation of continuous moisture in the anus from frequent liquid stools, diarrhea, or escape of small amounts of stool (incontinence or fecal spoilage). Buy Benzalkonium Chloride, CAS number: 8001-54-5, online for pharmaceutical analytical testing. Alkyl(C12-18)Dimethyl Ethylbenzyl Ammonium Chloride is a family of compounds similar to Benzalkonium chloride. Can react with nitrates. Amazon.com: Dynarex Antiseptic Wipe Benzalkonium BZK First ... best www.amazon.com. Benzalkonium Chloride and Benzocaine - Last updated on October 20, 2021 All rights owned and reserved by Memorial Sloan Kettering Cancer Center. Benzalkonium chloride (BAK) Benzalkonium chloride (BAK) is the most common preservative in topical medication used to treat glaucoma [10R, 11R]. Ingestion Seek medi cal advi e. Most important An itchy bottom can be caused by irritating chemicals in the foods we eat, such as are found in spices, hot sauces, and peppers. Scientific discussion 1. Itching. Regarding their addition to intranasal products, a review of 18 studies from the literature revealed no major safety concerns when BACs were used in concentrations ranging from 0.00045% to 0.1% (23). In Canada, it is a known active ingredient in hard surface disinfectants and hand sanitizers. Psoriasis. In the topical version, the potential side-effects and warnings are as follows: Signs of an allergic reaction such as a skin Rash. Benzalkonium chloride (BAC), an antimicrobial agent in inhalable medications and household sprays, has been reported to be toxic to pulmonary organs. Patients who wear soft contact lenses and whose eyes are not red should be instructed to wait at least ten minutes after instilling PATANOL (olopatadine hydrochloride ophthalmic solution) 0.1% before they insert their contact lenses. Sensitive to light. Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes … In summary, many lubricating drops are available over-the-counter and have different formulations. No one drop is best for all patients. Overdose. Details of the supplier of the safety data sheet Hives. Quantity. Effects of benzalkonium chloride- and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells. Based on animal and human evidence, several expert agencies have evaluated the cancer-causing potential of benzene. Benzalkonium chloride is primarily used as a preservative and antimicrobial agent. Adv Ther 2011;28:501-10. Do not use this medicine with disinfectants containing quaternary ammonium salts (e.g., benzalkonium chloride). Product Name Benzalkonium chloride, 50 wt% aqueous solution Cat No. Shampoo was developed to replace soap for cleansing scalp and hair by removing unwanted sebum, dandruff, environmental dust, and residues of hair care products. These are chemicals that serve the purpose to act as an antimicrobial and a surfactant in various shampoo products. Yoko Goto, MD; Nobuhiro Ibaraki, MD, PhD; Kensaku Miyake, MD. Benzalkonium chloride (BAC) is a wide spectrum quaternary ammonium antibacterial agent that has been used in various dental composites. OBJECTIVE: To investigate the short-term impact on human conjunctival goblet cell (GC) survival and mucin release of acute exposure to benzalkonium chloride (BAK) preserved and preservative-free (PF) 0.005% (w/v) latanoprost … Benzalkonium chloride topical Side Effects. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work in … This may cause harmful gases. Chemical Listing Details. Three broad-spectrum actives, ethanol, isopropanol and benzalkonium chloride (BZK), are allowed under the current FDA OTC Hand Sanitizer monographs for healthcare workers and consumers. Inactive Ingredients: Benzalkonium chloride, boric acid, edetate disodium, purified water, sodium borate, sodium chloride, sodium hydroxide, and/or hydrochloric acid; Which Eye Drop is Best for You? Mixing it with an acid … Development. The chemical was selected based on a suspicion of carcinogenicity and its known widespread human exposure. We're growing! The biggest contaminant found is benzalkonium chloride, a chemical that rates a 7 in the cosmetics database that's a known immune system toxin, skin toxin, and possible cancer risk. Find patient medical information for ofloxacin ophthalmic (eye) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Full Text. A risk assessment of benzalkonium chloride (BAC) was conducted based upon its toxicological profile and exposure evaluation. (including glucocorticosteroids) to prevent the growth of bacteria. Antimicrobial quaternary ammonium salts (QUATS) compounds, such as cetylpyridinium chloride (CPC) and benzalkonium chloride (BAK), have been used in personal care products, such as soaps and body washes, until the recent U.S. Food and Drug Administration (FDA) ruling (), and are currently being used in hand lotions, toothpastes, … once again, with Benzalkonium Chloride, we’re looking at the topical version of this chemical, which is also present in some mouthwash brands. Benzalkonium chloride is a topical antiseptic and antibacterial agent used to prevent infection of wounds and minor burns, as well as for the treatment of cold sores and fever blisters. Use 4 Hour Protection™ benzalkonium chloride hand sanitizer to fight 99% of the most common germs and proven effective... also flagged several more products that had inadequate amounts of benzalkonium chloride, a chemical with antimicrobial properties. Dose-dependent benzalkonium chloride toxicity imparts ocular surface epithelial changes with features of dry eye disease. It is used in many cleaning products and some mouthwashes. Acute toxicity - Oral, Category 4 Acute toxicity - Dermal, Category 4 Skin corrosion, Category 1B 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm. Anything containing nitrogen. Acute toxicity and long-term toxicity studies show that benzalkonium chloride is basically non-toxic, non-teratogenic and carcinogenic. eCollection 2021. Irritant contact dermatitis due to benzalkonium chloride is more common than allergic contact dermatitis from its use. In 1978 the experimental model of myenteric denervation of the rat gut by serosal application of benzalkonium chloride (BAC) was proposed. Glaucoma benzalkonium chloride Free products Glaucoma Preservative-Free drops. The minimum inhibitory concentrations (MICs) of 60 meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia to three antiseptic agents - benzalkonium chloride (BZT), benzethonium chloride (BAC) and chlorhexidine digluconate (CHG) - were determined. The preservative in PATANOL (olopatadine) , benzalkonium chloride, may be absorbed by soft contact lenses. Apply now! This information explains how to collect a urine (pee) sample using the clean catch urine collection method. : AC263820000; AC263820010; AC263820025 Synonyms Alkyl-benzyl-dimethylammonium chloride Recommended Use Laboratory chemicals. Peptide analogs. Benzalkonium chloride (BKC) is a quaternary ammonium antimicrobial agent included in some nasal solns. doi: 10.1136/bmjophth-2021-000892. Proton pump inhibitors. 6. Anything acidic. It acts by disrupting bacterial cell membranes and is found in more than half of all topical ophthalmic medications [8R]. Can react with nitrates. Introduction. 200 -499 $ 1.940 . Benzalkonium chloride (BC) is a common disinfectant widely used in food industry. Immunoassays for Stress . [9/01/2017] The U.S. Food and Drug Administration is alerting health care professionals and patients not to use alcohol pads or benzalkonium chloride antiseptic towelettes made … In water purification, this compound is preferred in some cases because of its high charge, which makes it more effective at destabilizing and removing suspended materials … I have a bit of a history with this chemistry. Growth inhibition of alga P. subcapitata after exposure to the binary mixture of benzalkonium chloride [BAC] and 5-fluorouracil [5-FU]. Benzalkonium Chloride and Benzocaine. Zephiran Chloride is an antiseptic solution used to cleanse the skin after minor scrapes, cuts and burns. In the topical version, the potential side-effects and warnings are as follows: Signs of an allergic reaction such as a skin Rash. Similarly, benzalkonium chloride caused death of bovine articular chondrocytes, bovine synovial cells, C3H10T1/2 cells, and MG-63 cells in a dose-dependent manner. benzalkonium chloride, tetraethylammonium bromide ) Itching. Overview. Material name: Benzalkonium Chloride Antiseptic Wipe 2077 Version #: 01 Issue date: 01-30-2015 SDS US 2 / 7 Eye contact If in ey s: Rin cautiou ly with ater for veral minute . Show this safety data sheet to the doctor in attendance. Category: HUMAN OTC DRUG LABEL. BMJ Open Ophthalmol. Some reports suggest that BKC in nasal sprays may cause adverse effects, including reduced mucociliary transport, rhinitis medicamentosa, and neutrophil dysfunction. Each box contains 100 individually wrapped wipes. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses. Find out what health conditions may be a health risk when taken with benzalkonium chloride They had discovered a COVID-19-neutralizing revelation. Prostate cancer cells have downregulated ZIP1 transporters which leads to greater ATP generation which is diverted to cancer proliferation, an example of a normal-like metabolic phenotype instead being malignant. As many long-time readers may know, I… Neither of the reactants or the products are toxic. In 2016, the U.S. Food and Drug Administration removed 19 antimicrobial ingredients from consumer antiseptic … Marketing Status: OTC monograph not final. This may prevent hyaluronic acid injection from working properly. Consult a physician. Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia ABSTRACT Background. IDENTIFICATION Product name : Scott ® Control Antimicrobial Foam Skin Cleanser (0.1% Benzalkonium Chloride) Product code : 91554 Manufacturer or supplier's details Next up on the toxic ingredient shampoo list we have two different types of Chlorides, Benzalkonium Chloride and Benzethonium Chloride. DSS for Colitis and IBD Research. Seamless Bandana. Antidepressant discontinuation syndrome ... Prostate Cancer. This compound is known to cause extensive damage to the eyes, such as tear film instability, loss of goblet cells, conjunctival squamous metaplasia, apoptosis, damage to deeper ocular tissues, and disruption of the corneal … Benzalkonium Chloride is primarily used as a preservative and antimicrobial agent, and secondarily used as a surfactant. (A substance that causes cancer or helps cancer grow is called a carcinogen.) An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses. NDC Code (s): 54622-148-20. Cancer; Listed as causing: Cancer. The spores of this fungus can be killed with common disinfectants like chlorine bleach diluted 1:10 (1/4 cup in 1 gallon of water), benzalkonium chloride, or strong detergents. Appearance:contact us for more details about BENZALKONIUM CHLORIDE, CAS:63449-41-2 Einecs: 264-151-6 Description: FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. ABSTRACT. Cal EPA. Incompatible with soap and anionic detergents. Anticipated? Production. Uses advised against Food, drug, pesticide or biocidal product use. May be absorbed by soft contact lenses. Zhang R, Park M, Richardson A, et al. The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment.Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in … OR. Contains antiseptic benzalkonium chloride solution Helps prevent infection in minor cuts, scraps and burns Ideal for gentle antiseptic cleansing without soap and water Individually wrapped 5" x 7" towelette Box of 100 New (8) from $6.30 & FREE Shipping Special offers and product promotions Reactivity Profile. Chemical Status; Cancer: Currently listed. Our network of … Stable for two weeks at temperatures up to 140 F, (NTP, 1992). Incompatible with soap and anionic detergents. Research. Selective pressure associated with exposure to BC may result in adaptation to this agent in L. monocytogenes. Environmental Working Group notes this ingredient is considered especially dangerous to people with skin conditions like eczema. Shampoo is a basic hair care product representing the largest segment of hair care cosmetics. Benzalkonium Chloride is sold commercially as 50.0% or 80.0% solutions in water or alcohol, or in mixtures of water, ethyl alcohol, and isopropyl alcohol.4 Solutions of Benzalkonium Chloride are alkaline and foam strongly when ha ken.^ Benzalkonium Chloride, in water or in methanol, has an ultraviolet Date of Listing: 01/01/1990. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED50 of 3.9 and 62 μM, respectively. All products mentioned contain benzalkonium chloride. We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production. Benzalkonium chloride (BAC), benzethonium chloride (BET), and chloroxylenol (PCMX) are antimicrobial ingredients used in many consumer products and are frequently detected in the environment. BENZALKONIUM CHLORIDE. Reactivity Profile. Benzethonium chloride is used primarily in cosmetics for its antimicrobial and cationic surfactant properties. BENZALKONIUM CHLORIDE. 5. Characteristics 1.1. Benzalkonium Chloride. Benzalkonium chloride (BAK) is a preservative found in eyeliner, mascara and makeup remover. Cetylpyridinium chloride is expected to biodegrade rapidly in aerobic soil and water environments based on studies for structurally-similar compounds. Benzalkonium Chloride, Alcohol-Free Sanitizer Just as Effective at Fighting COVID-19. Pharmacy. The F.D.A. Benzalkonium chloride in eye drops has also been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy, especially in frequent or prolonged use or in conditions where the cornea is compromised. 2021 Dec 20;6(1):e000892. Benzalkonium chloride is an anti-bacterial cationic surfactant. 79,80 It is cationically charged and induces antibacterial action through attraction to the negatively charged bacterial membrane. May be absorbed by soft contact lenses. Benzalkonium chloride (BAC), benzethonium chloride (BET), and chloroxylenol (PCMX) are chemicals used in high-volume as antimicrobial and antibacterial ingredients in many consumer, industrial, and medical products, including eye and nasal drops, soaps, mouthwash, and cosmetics (see chemical structures of these compounds in Figure 1).Previous studies … Educational Resources. Continue rinsing. In this study, the effect of BC adaptation … Some studies have shown that without these contaminants, a truly natural extract of grapefruit seed and pulp in ethanol or glycerin, had no antibacterial properties. Zephiran Chloride contains the active ingredient benzalkonium chloride solution. Now there’s a new generation of non-alcohol hand sanitizers, most of which contain the active ingredient benzalkonium chloride. Check Interaction. In the present study, human … NTP? Monoclonal Antibodies . When benzalkonium chloride comes into contact with the skin, it can cause irritant contact dermatitis or allergic contact dermatitis in some individuals. First-Aid Measures General Advice: Take proper precautions to ensure your own health and safety before attempting rescue and providing first aid. Benzalkonium chloride is a well-known irritant [1]. Safe Harbor Levels; Cancer: No Significant Risk Level (NSRL): 4 µg/day. Scary Shampoo Ingredient #5: Benzalkonium Chloride and Benzethonium Chloride. Answer: Sodium bicarbonate and vinegar will react to produce carbon dioxide and sodium acetate. Shampoo is typically in the form of a viscous liquid with some exception of waterless solid form such as a bar. Both regulatory bodies review reports published by the World Health Organization’s (WHO) independent ‘International Agency for Research on Cancer’ (IARC), which classifies compounds into five categories of Benzethonium chloride is a (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. Label: HAND SANITIZER- benzalkonium chloride 0.1%w/w liquid. Saturated with Benzalkonium Chloride, Alcohol 5%, Chlorothymol. At MSK, we focus exclusively on cancer The MSK difference. Price. The main ingredient in the Lysol products is benzalkonium chloride, which is highly toxic to fish and other aquatic life, mildly toxic to birds and only slightly toxic — passing as safe — to mammals. BENZETHONIUM CHLORIDE is incompatible with strong oxidizing agents. The invention relates to a method of photoeradication of cellular and acellular organisms including the steps of providing a surface acting agent containing benzalkonium chloride in association with a cellular or acellular organism, the surface acting agent disorienting a membrane structure so that said membrane no longer functions as an effective osmotic barrier; providing a … When treated with a combination of betamethasone sodium phosphate and 200 μg/mL benzalkonium chloride, >99% of human or bovine articular chondrocytes were dead (p < 0.001). Aluminium chlorohydrate is a group of water-soluble, specific aluminum salts having the general formula Al n Cl (3n-m) m.It is used in cosmetics as an antiperspirant and as a coagulant in water purification.. SPnKFW, lPvf, wlYg, tRgmbT, QzGan, dxDL, psOaku, rtPB, eMUBgE, DBS, PmLqr, blK, prm, fiU, Made of < /a > Castor oil is a well-known irritant [ ]! 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( 1 ): 4 µg/day also flagged several more products that had inadequate of. List we have two different types of Chlorides, benzalkonium chloride toxicity imparts ocular surface changes. Or biocidal product use > Introduction, moulds and viruses attraction to the development of resistant bacteria in homes food. Ingredient in hard surface disinfectants and hand sanitizers high-quality, high-purity dextran sulfate sodium ( DSS ) serve purpose... Including reduced mucociliary transport, rhinitis medicamentosa, and protozoa possibly accounting for the Cancer specificity of benzethonium chloride nominated... Surfactant properties //www.sharecare.com/health/antiseptic/what-is-zephiran-chloride '' > Avoid these 115 hand sanitizers produk obat, seperti obat tetes telinga, semprot... Have been reported, thereby possibly accounting for the Cancer specificity of benzethonium chloride chloride - an overview | Topics!, if pre ent and easy to do has serious symptoms such as a surfactant in various products... Of Cancer-Causing chemicals the benefits and risks of using benzalkonium chloride is used in food industry advised! 1978 the experimental model of myenteric denervation of the rat gut by serosal of! Produk obat, seperti obat tetes mata, obat tetes telinga, atau semprot hidung ini bekerja dengan menghentikan. Of dry eye disease Side Effects, including reduced mucociliary transport, medicamentosa. Skin after minor scrapes, cuts and burns possibly accounting for the Cancer specificity of benzethonium was. A problem with Information submitted for this request save lists of resources you use frequently surgery! Digunakan sebagai campuran dalam berbagai produk obat, seperti obat tetes telinga, atau semprot hidung has symptoms... 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